Response to the consultation on the draft Ionising Radiation (Medical Exposure) Regulations 2018

This document summarises responses to a DH consultation on transposing EU directives on protection against the dangers arising from medical exposure to radiation.

Methylnaltrexone bromide for treating opioid-induced constipation (terminated appraisal) - guidance (TA468)

NICE is unable to make a recommendation about the use in the NHS of methylnaltrexone bromide for treating opioid-induced constipation because no evidence submission was received from Swedish Orphan Biovitrum Ltd. We will review this decision if the company decides to make a submission.

Constipation in children and young people: diagnosis and management

Updated NICE clinical guidance on constipation in children. This guideline covers diagnosing and managing constipation in children and young people up to 18. It provides strategies to support the early identification and timely, effective treatment of constipation which will help improve outcomes for patients. It does not cover constipation caused by a specific condition.

This guideline includes recommendations on:

• history-taking and physical examination
• digital rectal examination
• clinical investigations and management
• diet and lifestyle
• psychological interventions
• antegrade colonic enema procedure
• information and support