The cutting edge - Micro-CT for quantitative toolmark analysis of sharp force trauma to bone.
Norman, D G; Watson, D G; Burnett, B; Fenne, P M; Williams, M A; et al.
Forensic science international 2018 February Vol. 283: 156-172.
Abstract
Toolmark analysis involves examining marks created on an object to identify the likely tool responsible for creating those marks (e.g., a knife). Although a potentially powerful forensic tool, knife mark analysis is still in its infancy and the validation of imaging techniques as well as quantitative approaches is ongoing. This study builds on previous work by simulating real-world stabbings experimentally and statistically exploring quantitative toolmark properties, such as cut mark angle captured by micro-CT imaging, to predict the knife responsible. In Experiment 1 a mechanical stab rig and two knives were used to create 14 knife cut marks on dry pig ribs. The toolmarks were laser and micro-CT scanned to allow for quantitative measurements of numerous toolmark properties. The findings from Experiment 1 demonstrated that both knives produced statistically different cut mark widths, wall angle and shapes. Experiment 2 examined knife marks created on fleshed pig torsos with conditions designed to better simulate real-world stabbings. Eight knives were used to generate 64 incision cut marks that were also micro-CT scanned. Statistical exploration of these cut marks suggested that knife type, serrated or plain, can be predicted from cut mark width and wall angle. Preliminary results suggest that knives type can be predicted from cut mark width, and that knife edge thickness correlates with cut mark width. An additional 16 cut marks walls were imaged for striation marks using scanning electron microscopy with results suggesting that this approach might not be useful for knife mark analysis. Results also indicated that observer judgements of cut mark shape were more consistent when rated from micro-CT images than light microscopy images. The potential to combine micro-CT data, medical grade CT data and photographs to develop highly realistic virtual models for visualisation and 3D printing is also demonstrated. This is the first study to statistically explore simulated real-world knife marks imaged by micro-CT to demonstrate the potential of quantitative approaches in knife mark analysis. Findings and methods presented in this study are relevant to both forensic toolmark researchers as well as practitioners. Limitations of the experimental methodologies and imaging techniques are discussed, and further work is recommended.
Full text available at
Showing posts with label bone. Show all posts
Showing posts with label bone. Show all posts
Monday, 5 February 2018
Thursday, 18 January 2018
RCOT announces revised guidelines for occupational therapy and total hip replacement
The Royal College of Occupational Therapists (RCOT) is delighted to announce the publication of the second edition of the practice guidelines for working with people undergoing total hip replacement. Endorsed by the British Hip Society, the new guidelines recognise in particular the changes in length of recommended stay for patients as well as the fact that this surgery is increasingly being performed on younger patients.
https://www.rcot.co.uk/practice-resources/rcot-practice-guidelines/hip
https://www.rcot.co.uk/practice-resources/rcot-practice-guidelines/hip
Labels:
bone,
hip,
joints,
MSK,
occupational_therapy,
orthopaedics,
rehabilitation,
surgery,
xMH
Monday, 8 January 2018
The cutting edge — Micro-CT for quantitative toolmark analysis of sharp force trauma to bone
Forensic Science International, Volume 283, Issue null, Pages 156-172
Toolmark analysis involves examining marks created on an object to identify the likely tool responsible for creating those marks (e.g., a knife). Although a potentially powerful forensic tool, knife mark analysis is still in its infancy and the validation of imaging techniques as well as quantitative approaches is ongoing. This study builds on previous work by simulating real-world stabbings experimentally and statistically exploring quantitative toolmark properties, such as cut mark angle captured by micro-CT imaging, to predict the knife responsible.
UHCW Research: B. Burnett
Toolmark analysis involves examining marks created on an object to identify the likely tool responsible for creating those marks (e.g., a knife). Although a potentially powerful forensic tool, knife mark analysis is still in its infancy and the validation of imaging techniques as well as quantitative approaches is ongoing. This study builds on previous work by simulating real-world stabbings experimentally and statistically exploring quantitative toolmark properties, such as cut mark angle captured by micro-CT imaging, to predict the knife responsible.
UHCW Research: B. Burnett
Thursday, 9 November 2017
NEOD001 for amyloid light-chain (AL) amyloidosis
Current treatments for AL amyloidosis target the plasma cells in the bone marrow, stopping the production of amyloid. NEOD001 has the potential to target amyloid protein directly in the bloodstream as well as within the organs. It would make the amyloid protein that is in the bloodstream ineffective, and would also clear amyloid protein deposits in tissues, nerves and organs. This has the potential to be the first treatment for AL amyloidosis that could restore organ function.
From the NIHR Innovation Observatory
Labels:
bone,
endocrinology,
evidence,
haematology,
innovation,
therapy,
xCom,
xMH
Monday, 27 March 2017
Calcium and phosphorus supplementation of human milk for preterm infants
Review to determine whether addition of calcium and phosphorus supplements to human milk leads to improved growth and bone metabolism of preterm infants without significant adverse effects
Cochrane Database of Systematic Reviews
Labels:
adverse_effects,
bone,
evidence,
metabolism,
neonatal,
nutrition,
premature_birth,
xCom,
xMH
Monday, 13 March 2017
The key to managing chronic joint pain
Mike Hurley from the Health Innovation Network (Academic Health Science Network for south London) explains how they are helping people to self-manage their chronic joint pain.
The Health Innovation Network (Academic Health Science Network for south London) has piloted a new approach to managing osteoarthritis (OA) in Primary Care – the Joint Pain Advisor.
The Joint Pain Advisor takes the form of up to four 30 minute face-to-face consultations between the Advisors and people with hip or knee OA. People attend an assessment where they discuss their lifestyle, challenges and personal goals and then jointly develop a personalised care plan which gives tailored advice and support based on NICE guidelines for the management of OA. People are then invited to attend reviews after three weeks, six-eight weeks and six months to access further tailored support and advice.
The Health Innovation Network (Academic Health Science Network for south London) has piloted a new approach to managing osteoarthritis (OA) in Primary Care – the Joint Pain Advisor.
The Joint Pain Advisor takes the form of up to four 30 minute face-to-face consultations between the Advisors and people with hip or knee OA. People attend an assessment where they discuss their lifestyle, challenges and personal goals and then jointly develop a personalised care plan which gives tailored advice and support based on NICE guidelines for the management of OA. People are then invited to attend reviews after three weeks, six-eight weeks and six months to access further tailored support and advice.
Labels:
arthritis,
bone,
case_studies,
innovation,
pain,
service_delivery,
xMH
Wednesday, 9 November 2016
Bone health in the elderly cancer patient: a SIOG Position Paper
Cancer Treatment Reviews. http://dx.doi.org/10.1016/j.ctrv.2016.10.004
More than a third of cancers are diagnosed in people over the age of 75. Androgen deprivation for prostate cancer and aromatase inhibitors in breast cancer accelerate age-related bone loss and increase fracture rates. BMD should be checked by dual energy X-ray absorptiometry at baseline and, dependent on risk, every 12-24 months. Sufficient calcium, vitamin D and exercise are part of primary fracture prevention. Resistance exercise in particular may improve functional activity and bone density. In men at increased fracture risk and women with postmenopausal early breast cancer, antiresorptive treatment is warranted to reduce fracture rate and to increase overall survival in breast cancer. Bone metastases (BM) are common in breast and prostate cancer and lytic bone lesions typical of multiple myeloma. They can cause fractures, pain and spinal cord compression, require surgery or radiation for symptom relief, and lead to hypercalcaemia. Multidisciplinary working with patients and carers can improve quality of life for elderly patients with BM and mitigate the adverse consequences of therapy. Bisphosphonates and other osteoclast inhibitors such as denosumab reduce this morbidity, improve quality of life and reduce pain. Especially in the elderly, attention should be paid to renal function and to risk factors for osteonecrosis with bone-modifying agents. Attention should also be paid to hypocalcaemia risk, which can be considerable in elderly men with metastatic prostate cancer and vitamin D deficiency. We urgently need further research specifically directed at assessing risks and benefits of bone targeted treatments in the growing population of elderly cancer patients.
UHCW Research: A. Arif
Friday, 30 September 2016
Bone-targeting drugs improve quality of life, but not survival in prostate cancer that has spread to bone
The drug zoledronic acid delayed the onset of bone complications by two months in men with prostate cancer that had spread to the bone. Though it did not increase overall survival, it improved quality of life by reducing important complications such as fractures and spinal cord compression.
From the NIHR Dissemination Centre
Radium-223 dichloride for treating hormone-relapsed prostate cancer with bone metastases
New Technology Appraisal Guidance from NICE:
Evidence-based recommendations on radium‑233 dichloride (Xofigo) for treating hormone-relapsed prostate cancer with bone metastases in adults.
Evidence-based recommendations on radium‑233 dichloride (Xofigo) for treating hormone-relapsed prostate cancer with bone metastases in adults.
Monday, 26 September 2016
NICE to recommend new drug to treat rare inherited bone disorder in children
NICE has published draft guidance recommending the drug asfotase alfa for children with perinatal- and infantile-onset hypophosphatasia – a very rare inherited condition affecting between one and seven babies each year in England.
Labels:
bone,
guidance,
medicines,
NICE,
paediatrics
Friday, 26 August 2016
Drugs that stimulate bone marrow might save lives in critically ill trauma patients
NIHR Signal -
Erythropoiesis stimulating agents (ESAs) might improve survival of critically ill patients after trauma. These drugs are synthetic versions of erythropoietin, a natural hormone produced by the kidneys.
This systematic review of trials in critical trauma patients found the survival benefit occurred without an increase in adverse effects, such as blood clots in the leg veins.
Thursday, 14 July 2016
Effects of calcium intake on bone mineral density and fracture risk
New Eyes on Evidence from NICE:
Two meta-analyses have found that increasing calcium intake, either through diet or using supplements, did not have a consistent effect on bone mineral density and incidence of fracture in people aged over 50 years
Two meta-analyses have found that increasing calcium intake, either through diet or using supplements, did not have a consistent effect on bone mineral density and incidence of fracture in people aged over 50 years
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